High-resolution view of compound promiscuity
نویسندگان
چکیده
منابع مشابه
High-resolution view of compound promiscuity
Compound promiscuity is defined as the ability of a small molecule to specifically interact with multiple biological targets. So-defined promiscuity is relevant for drug discovery because it provides the molecular basis of polypharmacology, which is increasingly implicated in the therapeutic efficacy of drugs. Recent studies have analyzed different aspects of compound promiscuity on the basis o...
متن کاملMulti-view, High-resolution Face Image Analysis
With advances in digital photography, people can obtain large-scale and high-quality pictures more easily. How to understand this large-scale and high-quality information and how to make use of this information to recover distortions in other images are two fundamental and challenging problems in computer vision and image processing. In this thesis, we solve these problems for face images so th...
متن کاملPubChem promiscuity: a web resource for gathering compound promiscuity data from PubChem
SUMMARY Promiscuity counts allow for a better understanding of a compound's assay activity profile and drug potential. Although PubChem contains a vast amount of compound and assay data, it currently does not have a convenient or efficient method to obtain in-depth promiscuity counts for compounds. PubChem promiscuity fills this gap. It is a Java servlet that uses NCBI Entrez (eUtils) web servi...
متن کاملExploring Compound Promiscuity Patterns and Multi-Target Activity Spaces
Compound promiscuity is rationalized as the specific interaction of a small molecule with multiple biological targets (as opposed to non-specific binding events) and represents the molecular basis of polypharmacology, an emerging theme in drug discovery and chemical biology. This concise review focuses on recent studies that have provided a detailed picture of the degree of promiscuity among di...
متن کاملHigh Quality Novel View Synthesis Based on Low Resolution Depth Image and High Resolution Color Image
In this paper, a new technique to generate high resolution depth image is proposed. First, a low resolution depth map is obtained by the time-of-flight depth camera. Then a high resolution depth map for a given view is generated by depth warping followed by depth value refinement taking into account the color information at the given view. The edge in the final depth map is then processed by bi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: F1000Research
سال: 2013
ISSN: 2046-1402
DOI: 10.12688/f1000research.2-144.v2